来自苦楝的细胞毒性川楝素型柠檬苦素类化合物。

Cytotoxic trichilin-type limonoids from Melia azedarach.

作者信息

Takeya K, Quio Z S, Hirobe C, Itokawa H

机构信息

Department of Natural Medicines, Tokyo University of Pharmacy & Life Science, Japan.

出版信息

Bioorg Med Chem. 1996 Aug;4(8):1355-9. doi: 10.1016/0968-0896(96)00128-9.

DOI:10.1016/0968-0896(96)00128-9

PMID:8879558

Abstract

Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay.

摘要

从苦楝根皮提取物中分离出五种新的川楝素型柠檬苦素，分别命名为12-去乙酰川楝素I（1）、1-乙酰川楝素H（2）、3-去乙酰川楝素H（3）、1-乙酰-3-去乙酰川楝素H（4）、1-乙酰-2-去乙酰川楝素H（5），以及四种已知的川楝素，即苦楝毒素B1（6）、川楝素H（7）、川楝素D（8）和1,12-二乙酰川楝素B（9）。通过光谱手段阐明了其结构，并采用MTT法体外测试了它们对P388细胞的细胞毒性活性。