来自苦楝的具有细胞毒性的印楝素型柠檬苦素类化合物。

Cytotoxic azadirachtin-type limonoids from Melia azedarach.

作者信息

Takeya K, Qiao Z S, Hirobe C, Itokawa H

机构信息

Department of Natural Medicines, Tokyo University of Pharmacy & Life Science, Japan.

出版信息

Phytochemistry. 1996 Jun;42(3):709-12. doi: 10.1016/0031-9422(96)00044-1.

DOI:10.1016/0031-9422(96)00044-1

PMID:8768322

Abstract

Four new limonoids, 1-tigloyl-3,20-diacetyl-11-methoxymeliacarpinin, 3-tigloyl-1,20-diacetyl-11-methoxymeliacarpinin, 1-cinnamoyl-3-hydroxy-11-methoxymeliacarpinin, and 1-deoxy-3-methacrylyl-11-methoxymeliacarpinin, together with a known limonoid, 1-cinnamoyl-3-acetyl-11-methoxymeliacarpinin, were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopy.

摘要

从苦楝根皮提取物中分离出四种新的柠檬苦素，即1-惕各酰基-3,20-二乙酰基-11-甲氧基米仔兰苦素、3-惕各酰基-1,20-二乙酰基-11-甲氧基米仔兰苦素、1-肉桂酰基-3-羟基-11-甲氧基米仔兰苦素和1-脱氧-3-甲基丙烯酰基-11-甲氧基米仔兰苦素，以及一种已知的柠檬苦素1-肉桂酰基-3-乙酰基-11-甲氧基米仔兰苦素。通过光谱学对其结构进行了阐明。