Murphy P T, Sivakumaran M, Fahy G, Hutchinson R M
Department of Haematology, Leicester Royal Infirmary, UK.
Bone Marrow Transplant. 1996 Sep;18(3):641-2.
Topical retinoic acid has proved to be of variable benefit in a number of dry eye disorders of disparate aetiology, in which squamous metaplasia with keratinization of ocular epithelium is present. Its exact role in patients with dry eye however remains in dispute. We describe a case of severe dry eye due to chronic graft-versus-host disease, which was refractory to conventional therapy but which responded remarkably to topical retinoic acid with reversal of conjunctival keratinization and marked resolution of symptoms.
局部用维甲酸已被证明在多种病因各异的干眼病中疗效不一，这些干眼病存在眼表上皮鳞状化生伴角化。然而，其在干眼症患者中的确切作用仍存在争议。我们描述了一例因慢性移植物抗宿主病导致的严重干眼症病例，该病例对传统治疗无效，但局部用维甲酸后反应显著，结膜角化逆转，症状明显缓解。
