Hsueh P R, Hsiue T R, Wu J J, Teng L J, Ho S W, Hsieh W C, Luh K T
Department of Laboratory Medicine, National Taiwan University Hospital, Republic of China.
Clin Infect Dis. 1996 Sep;23(3):550-5. doi: 10.1093/clinids/23.3.550.
To our knowledge, Flavobacterium indologenes has never been reported as a cause of bacteremia in humans. F. indologenes bacteremia was diagnosed in 12 patients at a tertiary referral center in southern Taiwan between 1 January 1992 and 31 December 1994. Six of these patients had ventilator-associated pneumonia, two had primary bacteremia, and one patient each had pyonephrosis, peritonitis, biliary tract infection, and surgical wound infection. Five patients (42%) had malignancies, and three (25%) had multiple burns. Polymicrobial bacteremia was diagnosed in eight patients (67%). Two (17%) of the patients in this study died; both had polymicrobial bacteremia. Antimicrobial susceptibility testing of the blood isolates from the 12 patients showed that > 90% of the isolates were susceptible to piperacillin, cefoperazone, ceftazidime, and minocycline. The chromatograms of esterified fatty acids for the isolates were identical. F. indologenes should be considered an etiologic agent of bloodstream infection, especially in hospitalized patients with severe underlying diseases.
据我们所知，吲哚黄杆菌从未被报道为人类菌血症的病因。1992年1月1日至1994年12月31日期间，台湾南部一家三级转诊中心诊断出12例吲哚黄杆菌菌血症患者。其中6例患者患有呼吸机相关性肺炎，2例患有原发性菌血症，1例分别患有肾盂积脓、腹膜炎、胆道感染和手术伤口感染。5例患者（42%）患有恶性肿瘤，3例（25%）有多处烧伤。8例患者（67%）被诊断为多微生物菌血症。本研究中有2例患者（17%）死亡；二者均有多微生物菌血症。对这12例患者血液分离株进行的药敏试验表明，>90%的分离株对哌拉西林、头孢哌酮、头孢他啶和米诺环素敏感。分离株的酯化脂肪酸色谱图相同。吲哚黄杆菌应被视为血流感染的病原体，尤其是在患有严重基础疾病的住院患者中。
