Biggar R J, Rabkin C S
Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Hematol Oncol Clin North Am. 1996 Oct;10(5):997-1010. doi: 10.1016/s0889-8588(05)70380-4.
The magnitude for and risk factors of the two most important AIDS neoplasm, Kaposi's sarcoma and non-Hodgkin's lymphoma, are reviewed in detail. The association between AIDS and other cancers is mostly speculative because surveillance biases tend to favor detecting associations that may be spurious. The overall relative risk of other cancers appears, however, to be only twofold above that in the general population, with associations being most convincing for anal (but not cervical) cancer and leiomyosarcoma and possible also for Hodgkin's disease, testicular cancer, and conjunctival cancers.
本文详细综述了两种最重要的艾滋病相关肿瘤——卡波西肉瘤和非霍奇金淋巴瘤的发病率及危险因素。艾滋病与其他癌症之间的关联大多是推测性的,因为监测偏差往往有利于发现可能是虚假的关联。然而,其他癌症的总体相对风险似乎仅比普通人群高出两倍,其中肛门癌(而非宫颈癌)和平滑肌肉瘤的关联最具说服力,霍奇金病、睾丸癌和结膜癌的关联也有可能。