Chan T Y
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Hum Exp Toxicol. 1996 Sep;15(9):747-50. doi: 10.1177/096032719601500905.
Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and lipid solubility. Excessive usage of these preparations in patients receiving warfarin may result in adverse interactions and bleedings. Methyl salicylate in topical analgesic preparations may cause irritant or allergic contact dermatitis and anaphylactic reactions. Physicians should fully appreciate the potential dangers from topical preparations containing methyl salicylate.
水杨酸甲酯（冬青油）广泛存在于许多非处方擦剂、软膏、洗剂或药用油中，用于缓解肌肉骨骼疼痛。由于水杨酸甲酯呈液体浓缩形式且具有脂溶性，摄入后会造成严重、快速发作的水杨酸盐中毒威胁。在接受华法林治疗的患者中过量使用这些制剂可能会导致不良相互作用和出血。局部止痛制剂中的水杨酸甲酯可能会引起刺激性或过敏性接触性皮炎以及过敏反应。医生应充分认识到含有水杨酸甲酯的局部制剂的潜在危险。
