Lee K K, Chan T Y, Lee C W
Department of Pharmacy, The Chinese University of Hong Kong, Shatin, New Territories.
J Clin Pharm Ther. 1997 Aug;22(4):279-81. doi: 10.1046/j.1365-2710.1997.10375103.x.
In view of the toxic potential of medicated oils containing methyl salicylate, we have studied the existing packaging of 10 commonly used preparations from Hong Kong and Singapore and identified areas for improvement with respect to the prevention of poisonings. They were all packed in translucent bottles without child-resistant closures. The methyl salicylate content ranged from 15 to 67%. Many preparations also contained other potentially toxic ingredients in significant amounts, such as turpentine oil and camphor. The contents of the larger bottles could generally be emptied more easily because of the greater size of their openings. The product with the highest methyl salicylate content also had the biggest opening of all. The threat from ingestion of medicated oils containing methyl salicylate can probably be 'reduced' by: (i) using child-restraint closures; (ii) restricting the size of both the openings and the bottles; and (iii) reducing the methyl salicylate content.
鉴于含有水杨酸甲酯的药用油具有潜在毒性，我们研究了香港和新加坡10种常用制剂的现有包装，并确定了在预防中毒方面需要改进的地方。它们都装在半透明瓶子中，没有防儿童开启的瓶盖。水杨酸甲酯含量在15%至67%之间。许多制剂还含有大量其他潜在有毒成分，如松节油和樟脑。由于较大瓶子的开口更大，其内容物通常更容易倒空。水杨酸甲酯含量最高的产品开口也是所有产品中最大的。摄入含有水杨酸甲酯的药用油带来的威胁或许可以通过以下方式“降低”：（i）使用儿童限制盖；（ii）限制开口和瓶子的尺寸；（iii）降低水杨酸甲酯含量。
