Beighton P, Solomon L, Soskolne C L, Sweet M B
S Afr Med J. 1977 Jun 25;51(26):969-72.
The prevalence of gout and the frequency distribution of serum uric acid (SUA) concentrations have been studied in four South African populations. Approximately 450 respondents over the age of 15 years were investigated in each of the following: a tribal Xhosa community in Transkei; a rural Tswana community in the northwestern Transvaal; an urban Negro population in Johannesburg; and a Caucasian community in the same city. No case of gout was encountered in any of the Negro groups, while the prevalence among the urban Caucasians was 13/1 000 men and 3/1 000 women. The mean SUA concentrations showed two consistent trends: (i) the levels rose with age in all four populations and in both sexes; (ii) they were generally higher in men than in women throughout the age range. There was, moreover, an increase in SUA concentrations with increasing sophistication of lifestyle (P less than 0,01), the lowest levels occurring in the tribal Africans, and the highest in the urban communities. This latter finding could not be explained on a genetic basis, nor were there significant differences in physical configuration and nutritional status among the three Negro groups. It is suggested that hyperuricaemia, and possibly the clinical manifestations of gout, have a polygenic aetiology in which acculturation plays an important contributory role.
对南非四个群体中痛风的患病率以及血清尿酸（SUA）浓度的频率分布进行了研究。在以下每个群体中对约450名15岁以上的受访者进行了调查：特兰斯凯的科萨部落社区；西北德兰士瓦的农村茨瓦纳社区；约翰内斯堡的城市黑人人口；以及同一城市的白人社区。在任何黑人群体中均未发现痛风病例，而城市白人中的患病率为男性13/1000，女性3/1000。SUA平均浓度呈现出两个一致的趋势：（i）在所有四个群体以及两性中，SUA水平均随年龄增长而升高；（ii）在整个年龄范围内，男性的SUA水平普遍高于女性。此外，随着生活方式的日益复杂，SUA浓度升高（P<0.01），最低水平出现在非洲部落人群中，最高水平出现在城市社区。后一项发现无法用遗传因素来解释，而且这三个黑人群体在身体结构和营养状况方面也没有显著差异。有人提出，高尿酸血症以及痛风的临床表现可能具有多基因病因，其中文化适应起着重要的促成作用。
