Pritchard W S, Robinson J H, Guy T D, Davis R A, Stiles M F
Psychophysiology Laboratory, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA.
Psychopharmacology (Berl). 1996 Sep;127(1):55-62. doi: 10.1007/BF02805975.
Thirty-two subjects were tested in five double-blind sessions (16 subjects in the morning following overnight smoking abstention, and 16 in the afternoon following ad-lib smoking). In each session, subjects smoked one of five experimental (EX) cigarettes having the following FTC nicotine/"tar' yields in mg: 0.08/8.5, 0.17/9.1, 0.37/9.8, 0.48/9.8, and 0.74/10.4. In a sixth session, subjects smoked a 0.71/8.6 commercial "light' (CL) cigarette that was their usual brand. Before and after smoking, subjects subjectively rated their desire to smoke a cigarette of their usual brand and had blood samples drawn. Following smoking, subjects rated the cigarette on a variety of sensory dimensions; they also rated smoking satisfaction. Analysis of variance indicated that nicotine played an important sensory role for a variety of dimensions related to cigarette taste and sensory impact but not perceived draw. Principal-components analyses indicated that sensory factors were at least as important as nicotine pharmacology (indirectly indexed by the pre-to post-smoking rise in blood nicotine concentration) when considering smoking's overall effects on satisfaction, product acceptance, and reduction in desire to smoke.
32名受试者参加了5次双盲实验（16名受试者在夜间戒烟后的早晨进行测试，16名在自由吸烟后的下午进行测试）。在每次实验中，受试者吸食五支实验（EX）香烟中的一支，其联邦贸易委员会（FTC）尼古丁/“焦油”含量（毫克）分别为：0.08/8.5、0.17/9.1、0.37/9.8、0.48/9.8和0.74/10.4。在第六次实验中，受试者吸食他们常用品牌的一支尼古丁含量0.71/焦油含量8.6的商业“淡味”（CL）香烟。在吸烟前后，受试者主观评价他们吸食常用品牌香烟的欲望，并采集血样。吸烟后，受试者对香烟在各种感官维度上进行评分；他们还对吸烟满意度进行评分。方差分析表明，尼古丁在与香烟味道和感官影响相关的各种维度上发挥着重要的感官作用，但对吸阻没有影响。主成分分析表明，在考虑吸烟对满意度、产品接受度和吸烟欲望降低的总体影响时，感官因素至少与尼古丁药理学（通过吸烟前后血尼古丁浓度的升高间接衡量）同样重要。
