Levin E D, Rose J E, Behm F
Nicotine Research Laboratory, VA Medical Center, Durham, NC 27705.
Drug Alcohol Depend. 1990 Jun;25(3):273-9. doi: 10.1016/0376-8716(90)90152-5.
The satisfaction derived from smoking depends not only on the pharmacological effects of nicotine but also the sensory stimulation from smoke inhalation, particularly the tracheal 'scratch'. In a previous study, we found that a citric acid aerosol produces a tracheal 'scratch' and provides some of the same satisfaction as cigarette smoke. In the present study, we evaluated a new pocket-sized device for delivering a citric acid aerosol and examined some of the important variables for providing a satisfying substitute for cigarettes. In the first experiment, volunteers who smoked at least 10 cigarettes per day compared a citric acid aerosol (either alone or with flavor additives) to a cigarette and a placebo. The addition of cigarette smoke flavor was found to best enhance the satisfaction provided by the citric acid aerosol. In the second experiment, smokers were given compact citric acid inhalers to use throughout 8 h of cigarette deprivation. The degree of satisfaction was highly correlated with the intensity of throat sensation provided by the aerosol. This citric acid aerosol inhaler may provide a useful tool for smokers while trying to quit smoking.
吸烟带来的满足感不仅取决于尼古丁的药理作用，还取决于吸入烟雾的感官刺激，尤其是气管的“刺痛感”。在之前的一项研究中，我们发现柠檬酸气雾剂会产生气管“刺痛感”，并能提供与香烟烟雾相同的一些满足感。在本研究中，我们评估了一种新型袖珍装置，用于输送柠檬酸气雾剂，并研究了提供令人满意的香烟替代品的一些重要变量。在第一个实验中，每天至少吸10支烟的志愿者将柠檬酸气雾剂（单独使用或添加香料）与香烟和安慰剂进行比较。发现添加香烟烟雾香味能最好地提高柠檬酸气雾剂带来的满足感。在第二个实验中，吸烟者在8小时不吸烟期间使用紧凑型柠檬酸吸入器。满足程度与气雾剂产生的喉咙感觉强度高度相关。这种柠檬酸气雾剂吸入器可能为吸烟者在试图戒烟时提供一个有用的工具。
