Willis L R, Queener S F
Can J Physiol Pharmacol. 1977 Oct;55(5):1205-7. doi: 10.1139/y77-165.
Pentobarbital sleeping times and blood levels on arousal were determined in spontaneously hypertensive rats (SHR) and normotensive controls (WKR). Sleeping time for SHR was significantly less than for WKR, but blood levels of [14C]pentobarbital at awakening were not significantly different. The shorter sleeping time in SHR appears not to result from decreased brain sensitivity to pentobarbital. Instead, SHR appear to differ from WKR in the rate of metabolic clearance of the drug or in the distribution of the drug between blood and brain.
测定了自发性高血压大鼠（SHR）和正常血压对照大鼠（WKR）的戊巴比妥睡眠时间以及唤醒时的血药浓度。SHR的睡眠时间显著短于WKR，但唤醒时[14C]戊巴比妥的血药浓度无显著差异。SHR睡眠时间较短似乎并非由于大脑对戊巴比妥的敏感性降低。相反，SHR与WKR的差异似乎在于药物的代谢清除率或药物在血液与大脑之间的分布。
