Jha A, Stein G
Mayday University Hospital, Croydon, UK.
Acta Psychiatr Scand. 1996 Aug;94(2):101-4. doi: 10.1111/j.1600-0447.1996.tb09832.x.
In a retrospective study, 124 patients with depression who were concomitantly receiving ECT and benzodiazepines were compared with patients (matched for age, sex, diagnosis, and laterality of ECT) receiving ECT without benzodiazepines in order to investigate the efficacy of ECT in terms of therapeutic response and length of stay in hospital. Most of the subjects (84% of cases and 89% of controls) improved on ECT, but the benzodiazepine group of patients receiving unilateral ECT showed a significantly poorer response and a longer stay in hospital. No such difference was detected with the bilateral ECT. It is therefore concluded that prescription of benzodiazepines with ECT does compromise the therapeutic effect of unilateral ECT for depression.
在一项回顾性研究中，将124例同时接受电休克治疗（ECT）和苯二氮䓬类药物的抑郁症患者与（在年龄、性别、诊断和ECT治疗侧别方面相匹配的）接受ECT但未使用苯二氮䓬类药物的患者进行比较，以研究ECT在治疗反应和住院时间方面的疗效。大多数受试者（84%的病例和89%的对照）在ECT治疗后病情改善，但接受单侧ECT的苯二氮䓬类药物组患者的反应明显较差，住院时间更长。双侧ECT未检测到此类差异。因此得出结论，ECT联合使用苯二氮䓬类药物确实会损害单侧ECT治疗抑郁症的疗效。
