Peretti C S, Danion J M, Grangé D, Mobarek N
INSERM Unité 405, Département de Psychiatrie, Hôpitaux Universitaires,Strasbourg, France.
J Affect Disord. 1996 Nov 4;41(1):9-15. doi: 10.1016/0165-0327(96)00053-5.
The aim of this pilot study was to systematically assess the influence of bilateral, sine wave ECT on autobiographical memory of past subjective experiences related to melancholia. Twenty-one inpatients who met DSM-III-R criteria for a Major Depressive Episode, Melancholic Type, were included in the study. Twelve patients were treated by ECT (12 treatments), antidepressants and benzodiazepines; the comparison group comprised 9 patients treated by antidepressants and benzodiazepines. The Structured Interview Guide for the HDRS (SIGH-D) was used at admission and after the ECT treatment to standardize data collection about subjective experiences related to the depressive episode. Memory of subjective experiences related to melancholia was assessed with free-recall, cued-recall and recognition tasks. In addition, a free recall of events of the day on which the patients came to the hospital for their treatment was administered. These tasks were administered 1 week after the last treatment in the ECT-treated group and 4 to 6 weeks after the beginning of the treatment in the comparison group. Free-recall, cued-recall and recognition performances were significantly lower in the ECT-treated group than in the comparison group. No significant correlation was found between memory of events related to hospital admission and memory of subjective experiences related to depression. In conclusion, bilateral, sine wave ECT impairs autobiographical memory of subjective experiences related to melancholia in subjects tested 1 week after completion of a course of ECT.
这项试点研究的目的是系统评估双侧正弦波电休克疗法（ECT）对与忧郁症相关的过去主观经历的自传体记忆的影响。21名符合《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）中重度抑郁发作、忧郁型标准的住院患者被纳入研究。12名患者接受了ECT治疗（12次治疗）、抗抑郁药和苯二氮䓬类药物治疗；对照组包括9名接受抗抑郁药和苯二氮䓬类药物治疗的患者。在入院时和ECT治疗后使用汉密尔顿抑郁量表结构化访谈指南（SIGH-D）来规范关于与抑郁发作相关的主观经历的数据收集。通过自由回忆、线索回忆和再认任务来评估与忧郁症相关的主观经历的记忆。此外，还对患者前来医院接受治疗当天的事件进行了自由回忆。这些任务在ECT治疗组最后一次治疗后1周进行，在对照组治疗开始后4至6周进行。ECT治疗组的自由回忆、线索回忆和再认表现明显低于对照组。在与入院相关的事件记忆和与抑郁相关的主观经历记忆之间未发现显著相关性。总之，双侧正弦波ECT会损害在一个ECT疗程结束后1周接受测试的受试者中与忧郁症相关的主观经历的自传体记忆。
