Law C M, Shiell A W
MRC Environmental Epidemiology Unit, University of Southampton, Southampton, Southampton General Hospital, UK.
J Hypertens. 1996 Aug;14(8):935-41.
To assess the strength of evidence for an inverse relationship between blood pressure and birth weight.
A systematic review of the published literature.
Published studies describing the relationship between blood pressure and birth weight since 1956.
More than 66,000 subjects aged 0-71 years.
Thirty-four studies described the relationship of blood pressure with birth weight. The majority of the studies of children and adults showed that blood pressure fell with increasing birth weight. Studies of adolescents were inconsistent. In neonates there was a positive relationship between blood pressure and birth weight. The pattern with age was supported by the limited number of studies with repeated measures and was dependent neither on the method of analysis nor on work from a single academic group or country.
Blood pressure is inversely related to birth weight in children and in adults. The positive results in neonates and the inconsistency in adolescence may be related to the unusual growth dynamics during these phases of growth. Further studies should concentrate on the mechanisms which underlie the relationship.
评估血压与出生体重之间负相关关系的证据强度。
对已发表文献进行系统综述。
1956年以来描述血压与出生体重关系的已发表研究。
66000多名年龄在0至71岁之间的受试者。
34项研究描述了血压与出生体重的关系。大多数针对儿童和成人的研究表明，血压随出生体重增加而下降。青少年研究结果不一致。新生儿中，血压与出生体重呈正相关。年龄模式得到了有限数量重复测量研究的支持，且不依赖于分析方法，也不依赖于单个学术团体或国家的研究。
儿童和成人的血压与出生体重呈负相关。新生儿的阳性结果和青少年的不一致结果可能与这些生长阶段异常的生长动态有关。进一步的研究应集中在这种关系背后的机制上。
