Brambilla F, Maggioni M, Panerai A E, Sacerdote P, Cenacchi T
Ospedale Psichiatrico Pini, Milano, Italy.
Neuropsychobiology. 1996;34(1):18-21. doi: 10.1159/000119285.
beta-Endorphin (beta-EP) concentrations were measured in peripheral blood mononuclear cells of 10 elderly women with major depressive disorders, 10 age- and sex-matched healthy controls and 10 young healthy controls. beta-EP values were measured in resting condition and after stimulation with corticotropin-releasing hormone (CRH). In patients, beta-EP values were measured in drug-free condition and after 30 days of treatment with phosphatidylserine (BCPS), 200 mg/day, p.o. Basal and CRH-stimulated beta-EP concentrations were the same in patients and controls; in patients they did not change after BCPS, in spite of significant improvement of the depressive symptomatology.
在10名患有重度抑郁症的老年女性、10名年龄和性别匹配的健康对照者以及10名年轻健康对照者的外周血单核细胞中测量了β-内啡肽（β-EP）浓度。在静息状态下以及用促肾上腺皮质激素释放激素（CRH）刺激后测量β-EP值。在患者中，在无药物状态下以及用磷脂酰丝氨酸（BCPS）200毫克/天口服治疗30天后测量β-EP值。患者和对照者的基础和CRH刺激后的β-EP浓度相同；在患者中，尽管抑郁症状有显著改善，但BCPS治疗后β-EP浓度并未改变。
