Brambilla F, Maggioni M, Cenacchi T, Sacerdote P, Panerai A R
Ospedale Psichiatrico Pini, Milano, Italy.
J Affect Disord. 1995 Dec 24;36(1-2):51-6. doi: 10.1016/0165-0327(95)00059-3.
T-lymphocyte responses to phytohemoagglutinin (PHA) stimulation were examined in 10 elderly women with nonmelancholic Major Depressive Disorders (MDD), in 10 age- and sex-matched controls and in 10 young female controls, before and after in vivo stimulation with corticotropin-releasing hormone (CRH). The tests were repeated in MDD patients after 30 days of therapy with phosphatidylserine (BC-PS), 200 mg/day, p.o. T-lymphocyte responses to PHA stimulation did not differ in the three groups, and were not changed by CRH administration. BC-PS therapy, while significantly improving the depressive symptomatology, did not modify the T-lymphocyte response to PHA, either before or after CRH stimulation.
在10名患有非忧郁性重度抑郁症（MDD）的老年女性、10名年龄和性别匹配的对照者以及10名年轻女性对照者中，检测了促肾上腺皮质激素释放激素（CRH）体内刺激前后，T淋巴细胞对植物血凝素（PHA）刺激的反应。在用磷脂酰丝氨酸（BC-PS），200mg/天，口服，治疗30天后，对MDD患者重复进行了测试。三组中T淋巴细胞对PHA刺激的反应没有差异，且CRH给药后也未改变。BC-PS治疗在显著改善抑郁症状的同时，并未改变CRH刺激前后T淋巴细胞对PHA的反应。
