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巴尔干(地方性)肾病与食源性赭曲霉毒素A:食品调查的初步结果

Balkan (endemic) nephropathy and foodborn ochratoxin A: preliminary results of a survey of foodstuffs.

作者信息

Krogh P, Hald B, Plestina R, Ceović S

出版信息

Acta Pathol Microbiol Scand B. 1977 Jun;85(3):238-40. doi: 10.1111/j.1699-0463.1977.tb01702.x.

DOI:10.1111/j.1699-0463.1977.tb01702.x
PMID:888703
Abstract

Ochratoxin A is a nephrotoxic fungal metabolite (mycotoxin) occurring in foodstuffs. The compound is causally associated with mycotoxic porcine nephropathy, a disease comparable with a human kidney disease, Balkan endemic nephropathy. A preliminary survey of home-produced foodstuffs in areas of Yugoslavia revealed that contamination with ochratoxin A is more frequent in an area where Balkan endemic nephropathy is prevalent (endemic area) than in area where this disease is absent. This indicates higher exposure to foodborn ochratoxin A in the endemic area. Thus further evidence is provided supporting the hypothesis that ochratoxin A is a disease determinant of Balkan endemic nephropathyk0

摘要

赭曲霉毒素A是一种存在于食品中的具有肾毒性的真菌代谢产物(霉菌毒素)。该化合物与霉菌毒素性猪肾病存在因果关系,这是一种与人类肾脏疾病——巴尔干地方性肾病类似的疾病。对南斯拉夫地区自制食品的初步调查显示,在巴尔干地方性肾病流行的地区(病区),赭曲霉毒素A的污染情况比该疾病不存在的地区更为常见。这表明病区人群通过食物接触赭曲霉毒素A的情况更为严重。因此,进一步的证据支持了赭曲霉毒素A是巴尔干地方性肾病致病因素这一假说。

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1
Balkan (endemic) nephropathy and foodborn ochratoxin A: preliminary results of a survey of foodstuffs.巴尔干(地方性)肾病与食源性赭曲霉毒素A:食品调查的初步结果
Acta Pathol Microbiol Scand B. 1977 Jun;85(3):238-40. doi: 10.1111/j.1699-0463.1977.tb01702.x.
2
Ochratoxin A contamination of foodstuffs in an area with Balkan (endemic) nephropathy.巴尔干(地方性)肾病地区食品中的赭曲霉毒素A污染
Acta Pathol Microbiol Scand B. 1979 Aug;87(4):243-6. doi: 10.1111/j.1699-0463.1979.tb02433.x.
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Human exposure to ochratoxin A in areas of Yugoslavia with endemic nephropathy.南斯拉夫存在地方性肾病地区的人群对赭曲霉毒素A的接触情况。
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Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumours in Bulgaria.保加利亚人体血液中的赭曲霉毒素A与巴尔干地方性肾病及泌尿系统肿瘤的关系
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