Panotopoulos G, Ruiz J C, Raison J, Guy-Grand B, Basdevant A
Department of Internal Medicine and Nutrition, University Paris VI, Hôtel Dieu, France.
Maturitas. 1996 Aug;25(1):11-9. doi: 10.1016/0378-5122(96)01119-x.
Whether menopause per se influences fat distribution independently of the effect of aging remains controversial. The lack of consistency in the menopause related changes in body fat distribution may be the result of differences in the methods for measuring fat distribution or in the characteristics of the women studied. The aim of this cross sectional study in obese women was to compare total body composition and regional fat and lean distribution, in premenopausal, perimenopausal and postmenopausal women.
Body composition was assessed by dual energy X-ray absorptiometry (DEXA) in premenopausal (n = 26), perimenopausal (n = 24) and postmenopausal (n = 73) obese women with no intercurrent diseases.
It was shown that postmenopausal obese (n = 73) women had a higher proportion of total fat mass in the trunk and a lower proportion of total fat and lean mass in the femoral and leg regions than premenopausal women after adjustment for age and total fat mass. In the same analysis, perimenopausal women had a lower proportion of total fat in the leg and femoral regions and of total lean in the femoral region than premenopausal women; they had a regional body composition similar to that of postmenopausal women.
The present data indicate that in obese women, post menopause and perimenopause are associated with differences in fat and lean distribution, independently of age and total fat.
绝经本身是否独立于衰老影响脂肪分布仍存在争议。绝经相关的身体脂肪分布变化缺乏一致性，可能是由于测量脂肪分布的方法或所研究女性特征的差异所致。这项针对肥胖女性的横断面研究旨在比较绝经前、围绝经期和绝经后女性的总体成分以及局部脂肪和瘦组织分布。
采用双能X线吸收法（DEXA）对26名绝经前、24名围绝经期和73名绝经后无并发疾病的肥胖女性进行身体成分评估。
结果显示，在调整年龄和总脂肪量后，绝经后肥胖女性（n = 73）躯干中总脂肪量的比例高于绝经前女性，而股骨和腿部区域的总脂肪和瘦组织量比例低于绝经前女性。在同一分析中，围绝经期女性腿部和股骨区域的总脂肪比例以及股骨区域的总瘦组织比例低于绝经前女性；她们的局部身体成分与绝经后女性相似。
目前的数据表明，在肥胖女性中，绝经后和围绝经期与脂肪和瘦组织分布的差异有关，独立于年龄和总脂肪量。
