Andrykowski M A, Munn R K, Studts J L
Department of Behavioral Science, University of Kentucky College of Medicine, Lexington 40536-0086, USA.
Prev Med. 1996 Sep-Oct;25(5):527-36. doi: 10.1006/pmed.1996.0086.
Previous studies have reported high interest in genetic testing for risk for colon or breast-ovarian cancer. These studies, however, have used samples which might be atypical with regard to level of interest evident among the general U.S. population.
As part of an annual statewide telephone health survey, adults' (n = 649) interest in learning about their personal genetic predisposition for cancer was assessed.
High levels of interest in learning about a personal genetic predisposition for cancer in general (87%) and breast cancer in particular (93%) were expressed. Logistic regression analysis indicated that lack of interest was associated with less education, minority status, and less performance of other health-protective behaviors. Only 53% of respondents reported their understanding of genetics was "good" or "excellent."
While interest in learning of one's personal genetic predisposition for cancer was high, many individuals requesting testing may have a less than good understanding of genetics and the implications of test results. Furthermore, variables associated with lack of interest in learning about personal genetic risk for cancer in this study were similar to those which have been previously found to be associated with poor utilization of other cancer control activities such as breast or cervical cancer screening.
先前的研究报告称，人们对结肠癌或乳腺癌-卵巢癌风险的基因检测兴趣浓厚。然而，这些研究使用的样本在美国普通人群中可能在兴趣水平方面不具代表性。
作为全州年度电话健康调查的一部分，评估了成年人（n = 649）了解自身癌症遗传易感性的兴趣。
总体而言，人们对了解自身癌症遗传易感性（87%）尤其是乳腺癌遗传易感性（93%）兴趣浓厚。逻辑回归分析表明，缺乏兴趣与教育程度较低、少数族裔身份以及较少进行其他健康保护行为有关。只有53%的受访者表示他们对遗传学的理解为“良好”或“优秀”。
虽然人们对了解自身癌症遗传易感性兴趣浓厚，但许多要求进行检测的人对遗传学以及检测结果的影响可能了解不足。此外，本研究中与缺乏了解自身癌症遗传风险兴趣相关的变量，与先前发现的与乳腺癌或宫颈癌筛查等其他癌症控制活动利用率低相关的变量相似。
