Samuelson G, Bratteby L E, Berggren K, Elverby J E, Kempe B
Department of Clinical Physiology, University of Uppsala, Sweden.
Acta Paediatr. 1996 Sep;85(9):1033-8. doi: 10.1111/j.1651-2227.1996.tb14212.x.
The aim of this study was to evaluate the dietary iron intake of 15-year-old adolescents from two different regions of Sweden, in relation to their iron status. The study comprised 185 boys and 209 girls, randomly selected from the official population register. The iron intake was calculated from a 7-day record, and varied between 7 and 35 and 6 and 27 mg per day for boys and girls, respectively. The daily median intakes in boys and girls were 18.7 and 14.2 mg, respectively. S-ferritin, s-iron, and s-transferrin saturation, measured in all the subjects, did not differ significantly between the two regions. However, the mean serum ferritin concentration was significantly higher in the boys (36.4 micrograms l-1) than in the girls (29.4 micrograms l-1) (p < 0.001). Low s-ferritin levels, defined as s-ferritin < 12 micrograms l-1 were found in seven boys (3.7%) and in 29 girls (13.9%). None of the adolescents had iron deficiency anaemia, defined as Hb < 110 gl-1 in combination with s-ferritin < 12 micrograms l-1. Regression and correlation analyses did not show any significant correlation between dietary iron intake and s-ferritin, or between s-ferritin and haemoglobin (Hb), MCH and MCHC. A significant correlation was found, however, between s-ferritin and transferrin saturation (p < 0.005) in both sexes. When the adolescents who still had s-ferritin < 12 micrograms l-1 at a second blood examination were given a 6 weeks trial with oral iron therapy, all of them showed an increase both in s-ferritin and in blood Hb. The 95% confidence intervals of s-ferritin for 15-year-old Swedish boys and girls were defined as 11-90 and 7-85 micrograms l-1, respectively.
本研究旨在评估瑞典两个不同地区15岁青少年的膳食铁摄入量及其铁状态。该研究从官方人口登记册中随机选取了185名男孩和209名女孩。铁摄入量根据7天记录计算得出，男孩和女孩的每日摄入量分别在7至35毫克和6至27毫克之间。男孩和女孩的每日中位数摄入量分别为18.7毫克和14.2毫克。对所有受试者测量的血清铁蛋白（S-铁蛋白）、血清铁和转铁蛋白饱和度在两个地区之间无显著差异。然而，男孩的平均血清铁蛋白浓度（36.4微克/升）显著高于女孩（29.4微克/升）（p<0.001）。7名男孩（3.7%）和29名女孩（13.9%）的血清铁蛋白水平较低，定义为血清铁蛋白<12微克/升。没有青少年患有缺铁性贫血，缺铁性贫血定义为血红蛋白（Hb）<110克/升且血清铁蛋白<12微克/升。回归和相关分析未显示膳食铁摄入量与血清铁蛋白之间、血清铁蛋白与血红蛋白（Hb）、平均红细胞血红蛋白含量（MCH）和平均红细胞血红蛋白浓度（MCHC）之间存在任何显著相关性。然而，在两性中均发现血清铁蛋白与转铁蛋白饱和度之间存在显著相关性（p<0.005）。在第二次血液检查时血清铁蛋白仍<12微克/升的青少年接受为期6周的口服铁剂治疗试验后，他们的血清铁蛋白和血红蛋白均有所增加。15岁瑞典男孩和女孩血清铁蛋白的95%置信区间分别定义为11 - 90微克/升和7 - 85微克/升。
