Sinchak K, Roselli C E, Clemens L G
Department of Zoology, Michigan State University, USA.
Behav Neurosci. 1996 Jun;110(3):593-602. doi: 10.1037//0735-7044.110.3.593.
Most male B6D2F1 hybrid house mice continue to copulate after castration (continuers), whereas others do not (noncontinuers). Copulation in continuers appears estrogen dependent. Serum testosterone (T), 17 beta-estradiol (E2), and dihydrotestosterone (DHT), as well as aromatase activity (AA) and estrogen receptor (ER) levels in preoptic area (POA), hypothalamus (HYP), and amygdala (AM) were measured to determine if continuers and noncontinuers differ in estrogen physiology. In general, continuers and noncontinuers did not differ in serum steroid levels, AA, or ER levels. Castration reduced AA in the POA, HYP, and AM. Castration did not affect nuclear ER levels in the POA and HYP but reduced nuclear ER in AM. The data demonstrate that castrated B6D2F1 male mice continue to be under the influence of circulating nongonadal E2 that is important for copulation.
大多数雄性B6D2F1杂交家鼠在阉割后仍继续交配（持续交配者），而其他一些则不会（非持续交配者）。持续交配者的交配行为似乎依赖雌激素。测量血清睾酮（T）、17β-雌二醇（E2）、二氢睾酮（DHT），以及视前区（POA）、下丘脑（HYP）和杏仁核（AM）中的芳香化酶活性（AA）和雌激素受体（ER）水平，以确定持续交配者和非持续交配者在雌激素生理方面是否存在差异。总体而言，持续交配者和非持续交配者在血清类固醇水平、AA或ER水平上没有差异。阉割降低了POA、HYP和AM中的AA。阉割不影响POA和HYP中的核ER水平，但降低了AM中的核ER。数据表明，阉割后的B6D2F1雄性小鼠仍然受到循环中对交配很重要的非性腺E2的影响。
