Bauer L O, Mott A E
Department of Psychiatry, MC 2103, University of Connecticut Health Center, Farmington 06030, USA.
Drug Alcohol Depend. 1996 Sep;42(1):21-6. doi: 10.1016/0376-8716(96)01258-6.
Olfactory evoked potentials (OEP) were elicited by odorous and nonodorous stimuli in 50 adult subjects: 26 subjects with histories of either cocaine (n = 19) or alcohol (n = 7) dependence, 10 with histories of nicotine but no other drug dependence, 2 with clinical anosmia of peripheral origin, and 12 subjects without drug or olfactory disorders. The presentation of nonodorous stimuli (i.e. a nasal air puff) did not elicit OEP component amplitude and latency differences among the groups. However, the presentation of odorous stimuli elicited a significantly smaller P1 component in the cocaine-dependent and alcohol-dependent groups than in the normal control and nicotine-dependent groups. The P1 amplitude deficit in the cocaine-dependent group is consistent with case report data associating cocaine use with lesions of the peripheral and/or central olfactory apparatus.
在50名成年受试者中，通过有气味和无气味刺激诱发嗅觉诱发电位（OEP）：26名有可卡因（n = 19）或酒精（n = 7）依赖史的受试者，10名有尼古丁使用史但无其他药物依赖的受试者，2名有外周性临床嗅觉丧失的受试者，以及12名无药物或嗅觉障碍的受试者。无气味刺激（即鼻腔喷气）的呈现并未引发各组之间OEP成分的振幅和潜伏期差异。然而，有气味刺激的呈现诱发可卡因依赖组和酒精依赖组的P1成分明显小于正常对照组和尼古丁依赖组。可卡因依赖组的P1振幅缺陷与将可卡因使用与外周和/或中枢嗅觉器官损伤相关联的病例报告数据一致。
