Harada Hirofumi, Shiraishi Kimio, Kato Toshihiko
Department of Otorhinolaryngology, School of Medicine, Fukuoka University 7-45-1 Jonan-ku, Fukuoka 814-0180, Japan.
Clin Electroencephalogr. 2003 Oct;34(4):191-6. doi: 10.1177/155005940303400405.
We developed a device to record olfactory event-related potentials (OERP) from the human scalp. Methyl-cyclopentenolone was used as the odorant element. A total of 50 stimuli were delivered. Each stimulus lasted 0.5 sec and was delivered once every three inspirations. Normal OERPs were obtained with this device. The positive peak latencies were approximately 350 msec (P1) and 700 msec (P2), respectively. OERPs were also recorded in 40 patients with smell disorders. A positive response at about 300-400 msec was recorded in 7 patients (all females, 15-59 years old). The other 33 patients showed no response. The high potential area of this positive peak was located in the centro-occipital region of the scalp. The latency and the high potential area of this peak were similar to P1 recorded in normal subjects. The source of this peak was considered identical to that of P1. This may be a response to the trigeminal nerve during odor administration. P2 was not recorded in the patients with smell disorders. P2 may therefore be a response to the olfactory nerve.
我们研发了一种用于记录人类头皮嗅觉事件相关电位（OERP）的设备。使用甲基环戊烯醇酮作为气味元素。总共施加了50次刺激。每次刺激持续0.5秒，每三次吸气施加一次。用该设备获得了正常的OERP。正峰潜伏期分别约为350毫秒（P1）和700毫秒（P2）。还对40名嗅觉障碍患者进行了OERP记录。7名患者（均为女性，年龄15 - 59岁）记录到约300 - 400毫秒的阳性反应。其他33名患者无反应。该正峰的高电位区域位于头皮的中央枕区。该峰的潜伏期和高电位区域与正常受试者记录的P1相似。该峰的来源被认为与P1相同。这可能是气味施加过程中对三叉神经的反应。嗅觉障碍患者未记录到P2。因此，P2可能是对嗅神经的反应。
