Van der Vleuten C J, Gerritsen M J, De Jong E M, Elbers M, De Jongh G J, van de Kerkhof P C
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Acta Derm Venereol. 1996 Sep;76(5):387-91. doi: 10.2340/0001555576387391.
Micanol, in which dithranol is micro-encapsulated in crystalline monoglycerides, is easy to wash off and staining and irritation are inconspicuous. These features make it appropriate to use in an out-patient setting. In this study the immunohistochemical effects of this new dithranol formulation were studied and compared with UVB and the combination of these therapies in skin biopsies of 8 patients with psoriasis. Markers for epidermal differentiation, proliferation and cutaneous inflammation were assessed. The present study suggests that Micanol predominantly had diminishing effects on inflammation markers, hardly affecting the epidermis. UVB had a broad spectrum of reductions. It is feasible that the combination resulted in various synergistic effects. Previous studies, however, revealed a relative persistence of the inflammatory infiltrate with more effects on epidermal processes following dithranol treatment. Based on the present study and on previous studies, it is hypothesised that Micanol delivers the active substance more directly in the dermal infiltrate, leaving the epidermis relatively unaffected. This might explain the low irritancy of Micanol treatment.
咪康唑醇（地蒽酚微囊化于结晶单甘油酯中）易于洗净，染色和刺激不明显。这些特性使其适用于门诊环境。在本研究中，对这种新的地蒽酚制剂的免疫组织化学作用进行了研究，并与紫外线B以及这两种疗法联合使用时对8例银屑病患者皮肤活检组织的作用进行了比较。评估了表皮分化、增殖和皮肤炎症的标志物。本研究表明，咪康唑醇主要对炎症标志物有减轻作用，对表皮影响很小。紫外线B有广泛的降低作用。联合使用可能产生各种协同效应。然而，先前的研究表明，地蒽酚治疗后炎症浸润相对持续，对表皮过程有更多影响。基于本研究和先前的研究，推测咪康唑醇能将活性物质更直接地输送到真皮浸润部位，使表皮相对不受影响。这可能解释了咪康唑醇治疗刺激性低的原因。
