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接触炭黑粉尘对肺功能的影响。对德国卡尔绍伦市德固赛工厂677名员工开展的一项研究结果。

Effects on the lung function of exposure to carbon black dusts. Results of a study carried out on 677 members of staff of the DEGUSSA factory in Kalscheuren/Germany.

作者信息

Küpper H U, Breitstadt R, Ulmer W T

机构信息

Department of Occupational Medicine, Degussa AG, Frankfurt, Germany.

出版信息

Int Arch Occup Environ Health. 1996;68(6):478-83. doi: 10.1007/BF00377873.

Abstract

Spirometry, full-bodyplethysmography, and inhalation challenge tests are the most frequently used methods for lung function testing. In all, 677 examinations were performed among exposed employees at the Degussa carbon black plant in Kalscheuren/Germany using the above mentioned methods, in order to detect whether there is a measurable impact of carbon black fine dust on pulmonary function, or a higher prevalence of obstructive air-way diseases among the study candidates, and whether fine dust exposure is related to the prevalence of bronchial hyperresposiveness. Within the smokers' group carbon black dust exposure reveals a (minimal) impact upon the lung function of the study subjects. However, the impact of fine dust exposure within that group is less significant than the influence of smoking on pulmonary function. Nevertheless, smokers are displaying significant more frequently signs of obstructive airway diseases compared with nonsmokers. In the smokers' group we found 7.3% of study subjects with signs of obstructive airway diseases compared with 3.9% in the group of nonsmokers. No significant impact of fine dust exposure on lung function could be detected within former- and nonsmokers. The overall percentage of 5.1% is not higher than that of subjects with bronchial hyperresponsiveness in other comparable studies.

摘要

肺活量测定法、全身体积描记法和吸入激发试验是最常用的肺功能测试方法。在德国卡尔绍伦的德固赛炭黑工厂,对暴露的员工总共进行了677次上述方法的检查,以检测炭黑细粉尘是否对肺功能有可测量的影响,或研究对象中阻塞性气道疾病的患病率是否更高,以及细粉尘暴露是否与支气管高反应性的患病率相关。在吸烟者组中,炭黑粉尘暴露对研究对象的肺功能有(最小)影响。然而,该组中细粉尘暴露的影响不如吸烟对肺功能的影响显著。尽管如此,与不吸烟者相比,吸烟者出现阻塞性气道疾病体征的频率明显更高。在吸烟者组中,我们发现7.3%的研究对象有阻塞性气道疾病体征,而在不吸烟者组中这一比例为3.9%。在前吸烟者和不吸烟者中,未检测到细粉尘暴露对肺功能有显著影响。5.1%的总体比例并不高于其他类似研究中支气管高反应性受试者的比例。

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