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2,5-Hexanedione induced apoptosis in cultured mouse DRG neurons.

作者信息

Ogawa Y, Shimizu H, Kim S U

机构信息

Department of Public Health and Environmental Medicine, Jikei University School of Medicine, Tokyo, Japan.

出版信息

Int Arch Occup Environ Health. 1996;68(6):495-7. doi: 10.1007/BF00377875.

DOI:10.1007/BF00377875
PMID:8891791
Abstract
摘要

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1
2,5-Hexanedione induced apoptosis in cultured mouse DRG neurons.
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2
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3
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4
Up-regulation of miR-26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting PTEN in bupivacaine injured mouse dorsal root ganglia.miR-26a的上调通过抑制布比卡因损伤的小鼠背根神经节中的PTEN来促进神经突生长并改善细胞凋亡。
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5
Chloroquine-induced alterations in rat sensory ganglia cultivated in vitro. A light and electron microscope study.
Acta Neuropathol. 1972;22(3):208-21. doi: 10.1007/BF00684524.
6
Schwann cell abnormalities in 2,5-hexanedione neuropathy.2,5 -己二酮性神经病中的施万细胞异常
J Neurocytol. 1978 Aug;7(4):517-28. doi: 10.1007/BF01173995.
7
SR 57746A attenuates cytostatic drug-induced reduction of neurite outgrowth in co-cultures of rat dorsal root ganglia and Schwann cells.SR 57746A可减轻细胞生长抑制药物诱导的大鼠背根神经节与雪旺细胞共培养物中神经突生长的减少。
Neurosci Lett. 1996 Jan 12;203(1):9-12. doi: 10.1016/0304-3940(95)12251-6.
8
Decelerated transport and its mechanism of 2,5-hexanedione on middle-molecular-weight neurofilament in rat dorsal root ganglia cells.2,5-己二酮对大鼠背根神经节细胞中分子量神经丝的减速运输及其机制
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2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways.2,5-己二酮通过 proNGF/p75NTR 和 JNK 通路诱导大鼠脊髓神经元和 VSC4.1 细胞凋亡。
Biosci Rep. 2021 Apr 30;41(4). doi: 10.1042/BSR20204264.
2
NGF protects bone marrow mesenchymal stem cells against 2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal pathway.NGF 通过 Akt/Bad 信号通路保护骨髓间充质干细胞免受 2,5-己二酮诱导的细胞凋亡。
Mol Cell Biochem. 2019 Jul;457(1-2):133-143. doi: 10.1007/s11010-019-03518-7. Epub 2019 Mar 25.
3
2,5-Hexanedione mediates neuronal apoptosis through suppression of NGF via PI3K/Akt signaling in the rat sciatic nerve.

本文引用的文献

1
The relative neurotoxicity of methyl-n-butyl ketone, n-hexane and their metabolites.甲基正丁基甲酮、正己烷及其代谢产物的相对神经毒性。
Toxicol Appl Pharmacol. 1980 Mar 15;52(3):433-41. doi: 10.1016/0041-008x(80)90338-5.
2
In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy.体外证据表明神经丝的共价交联发生在γ-二酮神经病中。
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4979-82. doi: 10.1073/pnas.81.15.4979.
3
Further observations on in vitro and in vivo effects of 2,5-hexanedione on glyceraldehyde-3-phosphate dehydrogenase.
2,5-己二酮通过抑制神经生长因子（NGF）及其信号通路诱导大鼠坐骨神经神经元凋亡。
Biosci Rep. 2019 Feb 12;39(2). doi: 10.1042/BSR20181122. Print 2019 Feb 28.
4
2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway.2,5-己二酮通过抑制PI3K/Akt信号通路下调大鼠脊髓中的神经生长因子并诱导神经元凋亡。
PLoS One. 2017 Jun 27;12(6):e0179388. doi: 10.1371/journal.pone.0179388. eCollection 2017.
5
Taurine inhibits 2,5-hexanedione-induced oxidative stress and mitochondria-dependent apoptosis in PC12 cells.牛磺酸抑制2,5 -己二酮诱导的PC12细胞氧化应激和线粒体依赖性凋亡。
Ind Health. 2017 Apr 7;55(2):108-118. doi: 10.2486/indhealth.2016-0044. Epub 2016 Nov 11.
6
Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway.骨髓间充质干细胞通过 NGF/AKT 依赖性途径减轻 2,5-己二酮诱导的神经元凋亡。
Sci Rep. 2016 Oct 5;6:34715. doi: 10.1038/srep34715.
7
2,5-hexanedione induced apoptosis of rat bone marrow mesenchymal stem cells by reactive oxygen species.2,5-己二酮通过活性氧诱导大鼠骨髓间充质干细胞凋亡。
J Occup Health. 2016 May 25;58(2):170-8. doi: 10.1539/joh.15-0143-OA. Epub 2016 Mar 24.
8
2,5-hexanedione induced apoptosis in mesenchymal stem cells from rat bone marrow via mitochondria-dependent caspase-3 pathway.2,5-己二酮通过线粒体依赖的半胱天冬酶-3途径诱导大鼠骨髓间充质干细胞凋亡。
Ind Health. 2015;53(3):222-35. doi: 10.2486/indhealth.2014-0182. Epub 2015 Jan 29.
9
Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione.慢性暴露于2,5 -己二酮的大鼠神经组织中Bcl-2、Bax和Caspase-3的表达
Neurochem Res. 2007 Sep;32(9):1566-72. doi: 10.1007/s11064-007-9359-0. Epub 2007 May 11.
关于2,5 -己二酮对3 -磷酸甘油醛脱氢酶的体外和体内作用的进一步观察
Arch Toxicol. 1984 Sep;55(3):191-4. doi: 10.1007/BF00316127.
4
Toxic polyneuropathy produced by methyl N-butyl ketone.甲基正丁基甲酮引起的中毒性多发性神经病。
Science. 1974 Aug 30;185(4153):787-9. doi: 10.1126/science.185.4153.787.
5
Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure.体外和体内暴露于2,5 -己二酮所诱导的大鼠轴突细胞骨架蛋白的改变。
Toxicol Appl Pharmacol. 1985 Apr;78(2):235-47. doi: 10.1016/0041-008x(85)90287-x.
6
Uncoupling of cerebral glucose supply and utilization after hexane-2,5-dione intoxication in the rat.大鼠己烷-2,5-二酮中毒后脑葡萄糖供应与利用的解偶联
J Neurochem. 1987 Mar;48(3):816-23. doi: 10.1111/j.1471-4159.1987.tb05590.x.
7
Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat.2,5-己二酮和全氘代-2,5-己二酮在大鼠体内的比较神经毒性及形成吡咯的潜力
Toxicol Appl Pharmacol. 1988 Jan;92(1):75-85. doi: 10.1016/0041-008x(88)90229-3.
8
Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy.吡咯氧化和蛋白质交联是γ-二酮神经病发展过程中的必要步骤。
Chem Res Toxicol. 1988 May-Jun;1(3):179-85. doi: 10.1021/tx00003a009.
9
2,5-Hexanedione is a potent gliatoxin in in-vitro cell cultures of the nervous system.2,5 -己二酮是神经系统体外细胞培养中的一种强效神经胶质毒素。
Neurotoxicology. 1992 Spring;13(1):151-4.
10
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.通过核DNA片段化的特异性标记原位鉴定程序性细胞死亡。
J Cell Biol. 1992 Nov;119(3):493-501. doi: 10.1083/jcb.119.3.493.