Bickford P C, Shukitt-Hale B, Joseph J
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA.
Mech Ageing Dev. 1999 Nov;111(2-3):141-54. doi: 10.1016/s0047-6374(99)00063-9.
Aging is associated with a decline in motor coordination and the ability to learn new motor learning skills. This loss of function is correlated with a decline in cerebellar beta-adrenergic receptor function. We have examined the role of oxidative stress on this system by exposing young rats to normobaric hyperoxia. This exogenous oxidative insult results in a decline in cerebellar beta-adrenergic receptor function that resembles what is observed in normal aged rats. This effect of hyperoxia is blocked by antioxidants. We have also examined the effects of nutritional supplementation of aged rats with diets high in antioxidant capacity. Foods such as blueberries and spinach can prevent and/or reverse age-related declines in cerebellar noradrenergic receptor function.
衰老与运动协调性下降以及学习新运动技能的能力下降有关。这种功能丧失与小脑β-肾上腺素能受体功能下降相关。我们通过将幼鼠暴露于常压高氧环境来研究氧化应激对该系统的作用。这种外源性氧化损伤导致小脑β-肾上腺素能受体功能下降，类似于在正常老龄大鼠中观察到的情况。高氧的这种作用可被抗氧化剂阻断。我们还研究了用抗氧化能力高的饮食对老龄大鼠进行营养补充的效果。蓝莓和菠菜等食物可以预防和/或逆转与年龄相关的小脑去甲肾上腺素能受体功能下降。
