Gould T J, Bickford P C
Veterans Administration Medical Center, Denver, CO.
Brain Res. 1994 Oct 17;660(2):333-6. doi: 10.1016/0006-8993(94)91308-0.
We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.
我们研究了与年龄匹配的对照组相比，用自旋捕获剂N-叔丁基-α-苯基硝酮（PBN）进行为期2周的治疗是否能缓解21 - 22月龄雄性F344大鼠小脑去甲肾上腺素能功能的年龄相关缺陷。PBN治疗组大鼠的去甲肾上腺素能受体功能与年轻大鼠相似，而未治疗组大鼠的功能则是先前在老年大鼠中记录到的典型情况。因此，PBN治疗可能会逆转小脑去甲肾上腺素能受体功能的年龄相关缺陷。
