Mattson S N, Riley E P, Sowell E R, Jernigan T L, Sobel D F, Jones K L
Center for Behavioral Teratology, Department of Psychology, San Diego State University, California 92120, USA.
Alcohol Clin Exp Res. 1996 Sep;20(6):1088-93. doi: 10.1111/j.1530-0277.1996.tb01951.x.
Magnetic resonance imaging was conducted on six children and adolescents with fetal alcohol syndrome and seven matched normal controls. Detailed volumetric analyses demonstrated significant reductions in the cerebral vault, basal ganglia, and diencephalon in the children with fetal alcohol syndrome, compared with control children. In addition, the volume of the cerebellar vault was smaller than controls in 4 of the 6 children with fetal alcohol syndrome, although the group difference did not reach significance. When the basal ganglia were divided into the caudate and lenticular nuclei, both of these regions were significantly reduced in the children with fetal alcohol syndrome. Finally, when the overall reduction in brain size was controlled, the proportional volume of the basal ganglia and, more specifically, the caudate nucleus was reduced in the children with fetal alcohol syndrome. These results may relate to behavioral findings in both humans and animals exposed to alcohol prenatally.
对6名患有胎儿酒精综合征的儿童和青少年以及7名匹配的正常对照者进行了磁共振成像检查。详细的体积分析表明，与对照儿童相比，患有胎儿酒精综合征的儿童的脑颅、基底神经节和间脑体积显著减小。此外，6名患有胎儿酒精综合征的儿童中有4名的小脑颅体积小于对照组，尽管组间差异未达到显著水平。当将基底神经节分为尾状核和豆状核时，患有胎儿酒精综合征的儿童这两个区域均显著减小。最后，在控制了脑大小的总体减小后，患有胎儿酒精综合征的儿童基底神经节的比例体积，更具体地说是尾状核的比例体积减小。这些结果可能与产前接触酒精的人类和动物的行为发现有关。
