Mattson S N, Riley E P, Jernigan T L, Garcia A, Kaneko W M, Ehlers C L, Jones K L
SDSU/UCSD Joint Doctoral Program in Clinical Psychology 92120.
Neurotoxicol Teratol. 1994 May-Jun;16(3):283-9. doi: 10.1016/0892-0362(94)90050-7.
Prenatal alcohol exposure is known to cause damage to the central nervous system. This study sought to further elucidate the structural brain damage that occurs following prenatal alcohol exposure in both children and rats. Two children with histories of maternal alcohol abuse but who did not qualify for a diagnosis of Fetal Alcohol Syndrome (FAS), based on established criteria, underwent magnetic resonance imaging. Reduced volumes were found for the cerebrum and cerebellum. In addition, the proportional volume of the basal ganglia was reduced, although the proportional volumes of cortical and subcortical fluid, cortical gray matter, limbic and nonlimbic cortex, and diencephalic structures were unaffected. These findings are compared with our recent MRI findings in two cases of FAS. In addition, the caudate-putamen and ventricular areas were assessed in rats exposed to alcohol prenatally. Whereas the overall brain section area was not reduced in size, the area of the caudate-putamen was reduced and that of the ventricles was enlarged.
已知产前酒精暴露会对中枢神经系统造成损害。本研究旨在进一步阐明儿童和大鼠在产前酒精暴露后发生的脑部结构损伤。两名有母亲酗酒史但根据既定标准不符合胎儿酒精综合征（FAS）诊断的儿童接受了磁共振成像检查。发现大脑和小脑体积减小。此外，基底神经节的比例体积减小，尽管皮质和皮质下液体、皮质灰质、边缘和非边缘皮质以及间脑结构的比例体积未受影响。这些发现与我们最近在两例FAS病例中的MRI发现进行了比较。此外，对产前暴露于酒精的大鼠的尾状核-壳核和脑室区域进行了评估。虽然整体脑切片面积大小没有减小，但尾状核-壳核的面积减小，脑室面积增大。
