Pietinalho A, Ohmichi M, Hiraga Y, Löfroos A B, Selroos O
Mjölbolsta Hospital, Finland.
Sarcoidosis Vasc Diffuse Lung Dis. 1996 Sep;13(2):159-66. doi: 10.1007/BF00389839.
We compared the clinical picture of sarcoidosis in patients diagnosed at Mjölbolsta hospital in Finland in 1955-1987 with those diagnosed in Sapporo in 1964-1988. The female:male ratios showed a slight female predominance. The mean age (SD) at diagnosis was 41.5 (13.0) years at Mjölbolsta and 30.0 (15.4) years in Sapporo. In both series, half of the patients had been detected at mass x-ray surveys. The presenting symptoms varied considerably among the symptomatic patients. At Mjölbolsta hospital, 189 patients (33%) had cough, 21% fever, 21% general malaise, 18% dyspnoea, 18% erythema nodosum, 16% joint pain and only 27 patients (5%) had eye symptoms. In Sapporo, 245 patients (41%) had eye symptoms, 18 (4%) had enlarged peripheral lymph nodes, 14 (3%) had cough, 10 (2%) had fever. Erythema nodosum did not occur as a presenting symptom in Sapporo. The chest radiographs showed bilateral hilar lymphadenopathy (BHL, stage I) in 48% of the Mjölbolsta patients and in 57% of the Sapporo patients. Stage II lesions were seen in 39% and 20%, and stage III lesions in 12% and 5% respectively. Only 1% had a normal chest radiograph at Mjölbolsta hospital as compared with 18% in Sapporo. The Sapporo patients were more obstructive but the proportion of smokers was also higher. No difference in diffusion capacity was seen.
我们比较了1955年至1987年在芬兰Mjölbolsta医院确诊的结节病患者与1964年至1988年在札幌确诊的患者的临床表现。女性与男性的比例显示女性略占优势。Mjölbolsta医院确诊时的平均年龄（标准差）为41.5（13.0）岁，札幌为30.0（15.4）岁。在这两个系列中，一半的患者是在大规模X光检查中被发现的。有症状的患者中，出现的症状差异很大。在Mjölbolsta医院，189名患者（33%）有咳嗽，21%有发热，21%有全身不适，18%有呼吸困难，18%有结节性红斑，16%有关节疼痛，只有27名患者（5%）有眼部症状。在札幌，245名患者（41%）有眼部症状，18名（4%）有外周淋巴结肿大，14名（3%）有咳嗽，10名（2%）有发热。结节性红斑在札幌不是首发症状。胸部X光片显示，Mjölbolsta医院48%的患者有双侧肺门淋巴结肿大（BHL，I期），札幌患者中这一比例为57%。II期病变分别见于39%和20%的患者，III期病变分别见于12%和5%的患者。Mjölbolsta医院只有1%的患者胸部X光片正常，而札幌为18%。札幌的患者阻塞性病变更多，但吸烟者的比例也更高。在弥散能力方面未见差异。
