Burrows A M, Mooney M P, Smith T D, Losken H W, Siegel M I
Department of Anthropology, University of Pittsburgh, Pennsylvania, USA.
J Neurosurg. 1996 Nov;85(5):929-36. doi: 10.3171/jns.1996.85.5.0929.
Human unicoronal synostosis results in plagiocephaly of the cranial vault due to predictable compensatory growth patterns of the contralateral coronal, sagittal, and ipsilateral squamosal sutures. The present study describes the development of plagiocephaly and tests compensatory growth predictions in a naturally occurring rabbit model of uncorrected unicoronal synostosis. Cranial vault and sutural growth data were collected from serial x-ray films in 70 normal rabbits and 19 rabbits with congenital unicoronal synostosis from 1.5 to 18 weeks of age. One-way analysis of variance results revealed that rabbits with unicoronal synostosis had significant (p < 0.05) growth inhibition at both coronal sutures and the contralateral frontonasal suture and a significantly wider (p < 0.05) cranial vault compared to controls. Paired Student's t-tests between affected and unaffected sides of the vault in rabbits with synostosis revealed significant (p < 0.05) asymmetry, with ipsilateral coronal sutures growing less than contralateral ones. Gross qualitative examination of the adult brains revealed severe asymmetry and anteroposterior reduction on the ipsilateral side. These results demonstrate that this congenital rabbit model effectively simulates human cranial vault growth predictions from unicoronal synostosis and produces a plagiocephalic morphology.
由于对侧冠状缝、矢状缝和同侧鳞状缝可预测的代偿性生长模式，人类单冠缝早闭会导致颅穹窿斜头畸形。本研究描述了斜头畸形的发展，并在未经矫正的单冠缝早闭的自然发生的兔模型中测试代偿性生长预测。从70只正常兔和19只先天性单冠缝早闭兔1.5至18周龄的系列x光片中收集颅穹窿和缝线生长数据。单因素方差分析结果显示，与对照组相比，单冠缝早闭兔的冠状缝和对侧额鼻缝均有显著（p < 0.05）生长抑制，颅穹窿显著更宽（p < 0.05）。对单冠缝早闭兔颅穹窿患侧和未患侧进行配对学生t检验，结果显示存在显著（p < 0.05）不对称，同侧冠状缝生长小于对侧。对成年兔大脑进行大体定性检查，发现同侧存在严重不对称和前后径减小。这些结果表明，这种先天性兔模型有效地模拟了人类单冠缝早闭导致的颅穹窿生长预测，并产生了斜头畸形形态。
