Lvov D K, Samokhvalov E I, Tsuda F, Selivanov N A, Okamoto H, Stakhanova V M, Stakhgildyan I V, Doroshenko N V, Yashina T L, Kuzin S N, Suetina I A, Deryabin P G, Ruzaeva L A, Bezgodov V N, Firsova L A, Sorinson S N, Mishiro S
Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, Russia.
Arch Virol. 1996;141(9):1613-22. doi: 10.1007/BF01718286.
We tested hepatitis C virus (HCV) antibody in 4216 sera collected from healthy people living in European part of Russia (including Northern, North-Western, Central, Central-Blacksoil, Volga-Vyatka, Volga, and North-Caucasian regions), non-European part of Russia (the Urals, East-Siberia, and the Far-East regions) and Mongolia. Prevalence of HCV antibody varied significantly by regions, ranging from 0.7% in Central region of European part of Russia to 10.7% in Mongolia. Genotyping of HCV (into 1a, 1b, 2a, 2b, and 3a) was performed on 469 sera from blood donors and patients (in Russia, Moldova, Turkmenistan, and Mongolia) who were positive for both HCV antibody and RNA. Genotype 1b was the most dominant genotype irrespective of regions (68.9%), with the highest rate in Moldova (96%). HCV unclassifiable into genotypes 1a-to-3a was found in 28 (6.0%) samples: particularly 4 of 10 samples from Lipetzk were untypable. Overall, HCV genotypes in European part of Russia were more similar to those in European countries, while those in Eastern part of Russia more similar to China or Japan. Genotype distribution was not associated with the clinical expression of HCV disease: acute hepatitis, chronic hepatitis or liver cirrhosis.
我们检测了从居住在俄罗斯欧洲部分（包括北部、西北部、中部、中央黑土、伏尔加-维亚特卡、伏尔加和北高加索地区）、俄罗斯非欧洲部分（乌拉尔、东西伯利亚和远东地区）以及蒙古的健康人采集的4216份血清中的丙型肝炎病毒（HCV）抗体。HCV抗体的流行率因地区而异，范围从俄罗斯欧洲部分中部地区的0.7%到蒙古的10.7%。对来自俄罗斯、摩尔多瓦、土库曼斯坦和蒙古的469份HCV抗体和RNA均呈阳性的献血者及患者血清进行了HCV基因分型（分为1a、1b、2a、2b和3a型）。无论地区如何，1b型都是最主要的基因型（68.9%），在摩尔多瓦的比例最高（96%）。在28份（6.0%）样本中发现了无法归类为1a至3a型的HCV：特别是利佩茨克的10份样本中有4份无法分型。总体而言，俄罗斯欧洲部分的HCV基因型与欧洲国家的更相似，而俄罗斯东部的与中国或日本的更相似。基因型分布与HCV疾病的临床表型（急性肝炎、慢性肝炎或肝硬化）无关。
