Shioiri T, Kato T, Murashita J, Hamakawa H, Inubushi T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
Biol Psychiatry. 1996 Oct 15;40(8):785-93. doi: 10.1016/0006-3223(95)00487-4.
Using phosphorus-31 magnetic resonance spectroscopy (31P-MRS), we analyzed the brain phosphorous metabolism in 18 patients with panic disorder (PD) and in 18 sex-, age-, and handedness-matched normal controls (NC). All patients were receiving ongoing drug treatments for PD. The evaluation of phosphorous metabolism in the whole frontal lobes revealed no significant differences between the patients and controls in 31P metabolite levels, although the PD patients showed slightly decreased inorganic phosphate (Pi) concentration of the frontal lobes. Moreover, we found a significant asymmetry (left > right) of phosphocreatine (PCr) concentration in the frontal lobes in the patients with PD, suggesting that abnormalities of phosphorous metabolism are present in the frontal lobes of PD patients. Two patients in whom a limited panic episode occurred during measurements showed frontal lobe intracellular pH higher than that in the other patients and that in the NC, suggesting respiratory gaseous alkalosis due to hyperventilation in the anxiety state. 31P-MRS has potential for application in the assessment of brain abnormalities and anxiety state, such as that accompanied by hyperventilation, in PD patients.
我们使用磷-31磁共振波谱（31P-MRS）分析了18例惊恐障碍（PD）患者及18例性别、年龄和利手相匹配的正常对照者（NC）的脑磷代谢情况。所有患者均正在接受针对PD的药物治疗。对整个额叶磷代谢的评估显示，患者与对照者的31P代谢物水平无显著差异，尽管PD患者额叶的无机磷酸盐（Pi）浓度略有降低。此外，我们发现PD患者额叶中磷酸肌酸（PCr）浓度存在显著的不对称性（左侧>右侧），提示PD患者额叶存在磷代谢异常。在测量过程中发生有限惊恐发作的2例患者，其额叶细胞内pH高于其他患者及正常对照者，提示焦虑状态下过度通气导致呼吸性气体碱中毒。31P-MRS在评估PD患者的脑异常及焦虑状态（如伴有过度通气的情况）方面具有应用潜力。
