Murashita J, Yamada N, Kato T, Tazaki M, Kato N
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Psychiatry Clin Neurosci. 1999 Apr;53(2):199-201. doi: 10.1046/j.1440-1819.1999.00487.x.
Sleep deprivation (SD) has an antidepressant effect in some, but not all, patients with depression, although its biological mechanisms have not yet been characterized. We previously reported altered brain phosphorus metabolism measured by phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in patients with bipolar depression. We preliminarily examined effects of SD on phosphorus metabolism in the frontal lobes of 15 normal subjects using 31P-MRS. No significant differences of membrane phospholipid metabolism, high-energy phosphate metabolism and intracellular pH were found between before and after SD in these subjects. Further studies will be necessary to elucidate the physiological mechanism of SD for depressive patients.
睡眠剥夺（SD）对部分而非全部抑郁症患者具有抗抑郁作用，尽管其生物学机制尚未明确。我们之前报道过，双相抑郁症患者经磷-31磁共振波谱（31P-MRS）测量显示脑磷代谢改变。我们使用31P-MRS对15名正常受试者额叶的磷代谢受SD影响情况进行了初步研究。这些受试者在SD前后，膜磷脂代谢、高能磷酸代谢及细胞内pH均未发现显著差异。有必要开展进一步研究以阐明SD对抑郁症患者的生理机制。
