Mizuki N, Ohno S
Department of Ophthalmology, Yokohama City, University School of Medicine, Japan.
Rev Rhum Engl Ed. 1996 Jul-Sep;63(7-8):520-7.
Behçet's disease has been shown to be strongly associated with the human leukocyte antigen (HLA) B51, not only in the Japanese but also in many other ethnic groups living in the area that extends from the Middle East to Japan. Specific antigen presentation by B51 molecules may be involved in the development of Behçet's disease. Furthermore, studies of the HLA-C genotype conducted using a polymerase chain reaction-sequence specific primers method have suggested that the gene involved in the pathogenesis of Behçet's disease is not the HLA-C gene but some other gene located near the HLA-B gene. Polymorphic analysis of the Tau-a microsatellite located between the HLA-B and TNF genes have also indicated that the Behçet's disease gene is located near the HLA-B gene but is not the HLA-B51 gene itself. We and others believe that many important genes exist in the region located between the TNF and HLA-B or HLA-C genes, including the MIC, PERB, and NOB genes. In this paper, we review current data on genetic factors involved in the development of Behçet's disease.
白塞病已被证明与人类白细胞抗原（HLA）B51密切相关，不仅在日本人中如此，在从中东到日本这片区域居住的许多其他种族群体中也是如此。B51分子的特异性抗原呈递可能参与了白塞病的发病过程。此外，使用聚合酶链反应-序列特异性引物方法对白塞病进行的HLA-C基因型研究表明，参与白塞病发病机制的基因不是HLA-C基因，而是位于HLA-B基因附近的其他某个基因。对位于HLA-B和TNF基因之间的Tau-a微卫星进行的多态性分析也表明，白塞病基因位于HLA-B基因附近，但不是HLA-B51基因本身。我们和其他人认为，在TNF与HLA-B或HLA-C基因之间的区域存在许多重要基因，包括MIC、PERB和NOB基因。在本文中，我们综述了有关白塞病发病过程中遗传因素的当前数据。
