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Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis.

作者信息

Bernasconi S, Cinque P, Peri G, Sozzani S, Crociati A, Torri W, Vicenzi E, Vago L, Lazzarin A, Poli G, Mantovani A

机构信息

Istituto di Ricerche Farmacologiche Mario Negri DIBIT, Milan, Italy.

出版信息

J Infect Dis. 1996 Nov;174(5):1098-101. doi: 10.1093/infdis/174.5.1098.

DOI:10.1093/infdis/174.5.1098
PMID:8896515
Abstract

The CC chemokine monocyte chemotactic protein-1 (MCP-1) was markedly elevated in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected patients with cytomegalovirus (CMV) encephalitis. The MCP-1 CSF levels in CMV encephalitis were markedly higher than those in the CSF of HIV-infected patients with or without unrelated neurologic diseases, including progressive multifocal leukoencephalopathy, cryptococcal meningitis, toxoplasmic encephalitis, and primary lymphoma. Interleukin-8, RANTES, macrophage inflammatory protein (MIP)-1 alpha, and MIP-1 beta were not substantially increased in the CSF of CMV encephalitis patients. High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurologic disorders associated with HIV infection.

摘要

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