Cadenhead K S, Perry W, Braff D L
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0804, USA.
Biol Psychiatry. 1996 Nov 1;40(9):853-8. doi: 10.1016/0006-3223(95)00547-1.
Individuals with schizotypal personality disorder (SPD) are thought to be phenotypically related to individuals with schizophrenia. This assumption is partially supported by the fact that SPD patients have deficits on biological markers similar to those found in schizophrenia. Visual backward masking (VBM) performance and critical stimulus duration (CSD), measures of information processing found to be abnormal in schizophrenia patients, were assessed in 14 SPD and 21 comparison subjects. There was no significant difference between groups in VBM performance; however; there were significant correlations between VBM deficits and the number of SPD symptoms, as well as elevated scores on the Ego. Impairment Index (EII). Additionally, there was a trend (p = 056) toward elevations in CSD in the SPD versus the comparison group and CSD inflation appears to be most prominent in individuals with a greater number of social deficit symptoms and elevated physical anhedonia scores. These findings suggest an important relationship between symptoms of SPD and neurophysiologic deficits.
分裂型人格障碍（SPD）患者被认为在表型上与精神分裂症患者相关。SPD患者在生物学指标上存在与精神分裂症患者类似的缺陷，这一事实为该假设提供了部分支持。对14名SPD患者和21名对照受试者评估了视觉反向掩蔽（VBM）表现和临界刺激持续时间（CSD），这两种信息处理指标在精神分裂症患者中被发现异常。两组在VBM表现上无显著差异；然而，VBM缺陷与SPD症状数量之间存在显著相关性，同时自我损害指数（EII）得分也有所升高。此外，与对照组相比，SPD组的CSD有升高趋势（p = 0.056），并且CSD延长在具有较多社交缺陷症状和较高躯体快感缺失得分的个体中似乎最为明显。这些发现表明SPD症状与神经生理缺陷之间存在重要关系。
