Shinohara K, Shinohara T, Mochizuki N, Mochizuki Y, Sawa H, Kohya T, Fujita M, Fujioka Y, Kitabatake A, Nagashima K
Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Heart Vessels. 1996;11(3):113-22. doi: 10.1007/BF01745169.
To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the intensity of the VEGF signal was much higher in smooth muscle cells of arterioles adjacent to necrosis and in infiltrating macrophages than in myocytes around the site of the necrosis. This study suggests that levels of VEGF expression are high in smooth muscle cells and macrophages around infarcted areas after myocardial infarction and that VEGF may play a role in promoting collateral circulation and angiogenesis in human ischemic hearts.
为了确定可能影响侧支循环和血管生成的机制，我们研究了人心脏中血管内皮生长因子（VEGF）mRNA的表达。在非缺血性人心脏中，未在血管中检测到VEGF mRNA，但在心肌细胞中发现了该因子。在心肌梗死的心脏中，与坏死相邻的小动脉平滑肌细胞和浸润的巨噬细胞中的VEGF信号强度远高于坏死部位周围的心肌细胞。这项研究表明，心肌梗死后梗死区域周围的平滑肌细胞和巨噬细胞中VEGF表达水平较高，并且VEGF可能在促进人缺血性心脏的侧支循环和血管生成中发挥作用。
