Harangi F, Györke Z, Melegh B
Kerpel-Fronius Odön Children's Hospital of Baranya County, Pécs, Hungary.
Pediatr Nephrol. 1996 Oct;10(5):555-8. doi: 10.1007/s004670050159.
Both in vivo and in vitro studies suggest that macromolecules excreted in the urine, e.g. glycosaminoglycans (GAGs) may be inhibitors of kidney stone formation. We evaluated urinary GAG excretion in 22 children with calcium oxalate stones [8 with absorptive hypercalciuria, 6 with renal hypercalciuria (RH), 8 with normocalciuria], and in 20 age-matched controls. There was no significant difference between the two groups in the total urinary GAG level. In terms of the various GAG fractions, patients with RH excreted considerably less keratan sulphate and considerably more dermatan sulphate than the other patients and healthy controls. There was no difference between the two groups in condroitin sulphate, heparan sulphate and hyaluronic acid excretion. We conclude that there is no significant correlation between the formation of calcium oxalate stones and urinary GAG excretion.
体内和体外研究均表明，尿液中排泄的大分子物质，如糖胺聚糖（GAGs）可能是肾结石形成的抑制剂。我们评估了22例草酸钙结石患儿[8例吸收性高钙尿症、6例肾性高钙尿症（RH）、8例正常钙尿症]以及20例年龄匹配的对照者的尿GAG排泄情况。两组的总尿GAG水平无显著差异。就各种GAG组分而言，与其他患者和健康对照者相比，RH患者排泄的硫酸角质素明显更少，而硫酸皮肤素明显更多。两组在硫酸软骨素、硫酸乙酰肝素和透明质酸排泄方面无差异。我们得出结论，草酸钙结石的形成与尿GAG排泄之间无显著相关性。
