Caudarella R, Stefani F, Rizzoli E, Malavolta N, D'Antuono G
J Urol. 1983 Mar;129(3):665-7. doi: 10.1016/s0022-5347(17)52274-0.
In calcium lithiasis, pathogenesis inhibitors have a significant role to play which permits raising of the upper metastability limit in the urine, thus reducing the crystallization processes. The aim of this work is to evaluate glycosaminoglycans excretion and concentration in a group of patients with idiopathic calcium lithiasis, and in a control group for detecting possible differences between the 2 groups. Analysis of our results shows that no significant differences exist between the 24-hour average excretion of glycosaminoglycans in normal and stone forming subjects, but there was a significant difference in the mean concentration values between the 2 groups, either as whole or when separately considered with respect to normal or increased uric acid excretion. Particularly interesting was the correlation study between glycosaminoglycans and uric acid which shows a linear relationship with a positive slope in all groups but in stone formers with hyperuricosuria.
在钙结石症中，发病机制抑制剂发挥着重要作用，它能提高尿液中的亚稳上限，从而减少结晶过程。本研究的目的是评估一组特发性钙结石症患者以及一个对照组中糖胺聚糖的排泄量和浓度，以检测两组之间可能存在的差异。对我们研究结果的分析表明，正常人和结石形成者的糖胺聚糖24小时平均排泄量之间不存在显著差异，但两组的平均浓度值存在显著差异，无论是总体比较还是分别按尿酸排泄正常或增加来考虑。特别有趣的是糖胺聚糖与尿酸之间的相关性研究，结果显示在所有组中二者呈线性关系且斜率为正，但高尿酸尿症的结石形成者除外。
