通过光子相关光谱法测定脂质囊泡悬浮液中的粒径分布。
Determination by photon correlation spectroscopy of particle size distributions in lipid vesicle suspensions.
作者信息
Goll J H, Stock G B
出版信息
Biophys J. 1977 Sep;19(3):265-73. doi: 10.1016/S0006-3495(77)85586-0.
Abstract
A method of determining particle size distributions in lipid vesicle preparations is outlined. A vesicle suspension is modeled as a polydisperse mixture of spherical shells. The distribution of particle sizes in this mixture is approximated by a continuous, piecewise linear function called a first-order spline. Excellent simultaneous fits to photon correlation spectroscopy data gathered at several different angles are presented. An error analysis is included to indicate the resolution of the method.
摘要
概述了一种测定脂质囊泡制剂中粒径分布的方法。将囊泡悬浮液建模为球形壳的多分散混合物。该混合物中粒径的分布由一种称为一阶样条的连续分段线性函数近似。给出了对在几个不同角度收集的光子相关光谱数据的出色同时拟合。包含误差分析以表明该方法的分辨率。
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