Janssen P L, Hollman P C, Reichman E, Venema D P, van Staveren W A, Katan M B
Department of Human Nutrition, Wageningen Agricultural University, Netherlands.
Am J Clin Nutr. 1996 Nov;64(5):743-7. doi: 10.1093/ajcn/64.5.743.
Intake of acetylsalicylic acid reduces the risk of cardiovascular disease and is associated with a decreased risk for colorectal cancer. Amounts of salicylates in foods are thus of interest, but data are scarce and controversial. We gave 58 mumol (10.5 mg) pure acetylsalicylic acid or 66 mumol (9.1 mg) salicylic acid to six volunteers and recovered 77-80% in 24-h urine samples. Thus, urinary excretion is a valid indicator for intake of free forms of (acetyl)salicylic acid. To estimate the bioavailable salicylate contents of diets, we subsequently studied salicylate excretion in 17 volunteers from 14 countries and four continents who ate a wide variety of self-selected diets. Median 24-h urinary salicylate excretion was 10 mumol (range: 6-12 mumol). Values increased with the fiber content of the diet (r = 0.73), suggesting that vegetable foods are the main sources of salicylates. However, amounts of salicylates in a variety of diets are evidently low and probably insufficient to affect disease risk.
摄入乙酰水杨酸可降低心血管疾病风险，并与结直肠癌风险降低相关。因此，食物中水杨酸盐的含量备受关注，但相关数据稀缺且存在争议。我们给6名志愿者分别服用58微摩尔（10.5毫克）纯乙酰水杨酸或66微摩尔（9.1毫克）水杨酸，并在24小时尿液样本中回收了77%-80%。因此，尿排泄是（乙酰）水杨酸游离形式摄入量的有效指标。为了估计饮食中可生物利用的水杨酸盐含量，我们随后研究了来自四大洲14个国家的17名志愿者的水杨酸盐排泄情况，这些志愿者食用了各种自行选择的饮食。24小时尿水杨酸盐排泄中位数为10微摩尔（范围：6-12微摩尔）。排泄量随饮食中纤维含量增加而升高（r = 0.73），这表明植物性食物是水杨酸盐的主要来源。然而，各种饮食中水杨酸盐的含量显然较低，可能不足以影响疾病风险。
