Rouse D J, Owen J, Goldenberg R L, Cliver S P
Center for Obstetric Research, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35233-7333, USA.
JAMA. 1996 Nov 13;276(18):1480-6.
To quantitate the potential effectiveness and monetary costs of a policy of elective cesarean delivery for fetal macrosomia diagnosed by ultrasound.
A decision analytic model was constructed to compare 3 policies: (1) management without ultrasound; (2) ultrasound and elective cesarean delivery for estimated fetal weight of 4000 g or more (4000-g policy); and (3) ultrasound and elective cesarean delivery for estimated fetal weight of 4500 g or more (4500-g policy). The impact of maternal diabetes was analyzed separately. Probability data used in the decision analytic model were summarized from the literature and supplemented with unpublished data from the Collaborative Trial of Preterm Birth Prevention. Costs were estimated from the literature, regional reimbursements, and clinical practice data.
Rates of shoulder dystocia and permanent brachial plexus injury, and both the number of additional cesarean births and monetary costs per permanent brachial plexus injury averted.
In the baseline analysis for nondiabetic women, the ultrasound policies increased both the cesarean delivery rate and costs, while decreasing the rate of shoulder dystocia and brachial plexus injury. For each permanent brachial plexus injury prevented by the 4500-g policy, 3695 cesarean deliveries were performed at an additional cost of $8.7 million, vs 2345 cesarean deliveries and $4.9 million with the 4000-g policy. In the baseline analysis for diabetic women, with all 3 policies, rates of cesarean delivery, shoulder dystocia and brachial plexus injury, and total costs were higher than for nondiabetic women. However, more favorable ratios for both cesarean deliveries and cost per permanent injury avoided were observed: 443 deliveries and $930 000, respectively, with the 4500-g policy, and 489 deliveries and $880 000, respectively, with the 4000-g policy. Sensitivity analysis confirmed the general robustness of these findings.
For the 97% of pregnant women who are not diabetic, a policy of elective cesarean delivery for ultrasonographically diagnosed fetal macrosomia is medically and economically unsound. In pregnancies complicated by diabetes, such a policy appears to be more tenable, although the merits of such an approach are debatable.
量化针对超声诊断为巨大胎儿而采取的选择性剖宫产政策的潜在有效性和货币成本。
构建了一个决策分析模型,以比较三种政策:(1)不使用超声的管理方式;(2)对于估计胎儿体重4000克或以上进行超声检查及选择性剖宫产(4000克政策);(3)对于估计胎儿体重4500克或以上进行超声检查及选择性剖宫产(4500克政策)。分别分析了孕产妇糖尿病的影响。决策分析模型中使用的概率数据来自文献综述,并补充了早产预防协作试验的未发表数据。成本根据文献、地区报销情况和临床实践数据进行估算。
肩难产和永久性臂丛神经损伤的发生率,以及避免每例永久性臂丛神经损伤所需增加的剖宫产分娩数量和货币成本。
在非糖尿病女性的基线分析中,超声检查政策提高了剖宫产率和成本,同时降低了肩难产和臂丛神经损伤的发生率。对于4500克政策预防的每例永久性臂丛神经损伤,需进行3695例剖宫产,额外成本为870万美元;而4000克政策则需进行2345例剖宫产,成本为490万美元。在糖尿病女性的基线分析中,三种政策下的剖宫产率、肩难产和臂丛神经损伤发生率以及总成本均高于非糖尿病女性。然而,在避免永久性损伤方面,剖宫产分娩数量和成本的比例更为有利:4500克政策分别为443例分娩和93万美元,4000克政策分别为489例分娩和88万美元。敏感性分析证实了这些发现的总体稳健性。
对于97%的非糖尿病孕妇,针对超声诊断为巨大胎儿而采取的选择性剖宫产政策在医学和经济上是不合理的。在合并糖尿病的妊娠中,这种政策似乎更具合理性,尽管这种方法的优点仍有争议。