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胎儿生长测量指标在低危产科人群中预测肩难产的价值。

Fetal Growth Biometry as Predictors of Shoulder Dystocia in a Low-Risk Obstetrical Population.

机构信息

Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.

出版信息

Am J Perinatol. 2024 May;41(7):891-901. doi: 10.1055/a-1787-6991. Epub 2022 Mar 3.

Abstract

OBJECTIVE

This study aimed to evaluate fetal biometrics as predictors of shoulder dystocia (SD) in a low-risk obstetrical population.

STUDY DESIGN

Participants were enrolled as part of a U.S.-based prospective cohort study of fetal growth in low-risk singleton gestations ( = 2,802). Eligible women had liveborn singletons ≥2,500 g delivered vaginally. Sociodemographic, anthropometric, and pregnancy outcome data were abstracted by research staff. The diagnosis of SD was based on the recorded clinical impression of the delivering physician. Simple logistic regression models were used to examine associations between fetal biometrics and SD. Fetal biometric cut points, selected by Youden's J and clinical determination, were identified to optimize predictive capability. A final model for SD prediction was constructed using backward selection. Our dataset was randomly divided into training (60%) and test (40%) datasets for model building and internal validation.

RESULTS

A total of 1,691 women (98.7%) had an uncomplicated vaginal delivery, while 23 (1.3%) experienced SD. There were no differences in sociodemographic or maternal anthropometrics between groups. Epidural anesthesia use was significantly more common (100 vs. 82.4%;  = 0.03) among women who experienced SD compared with those who did not. Amniotic fluid maximal vertical pocket was also significantly greater among SD cases (5.8 ± 1.7 vs. 5.1 ± 1.5 cm; odds ratio = 1.32 [95% confidence interval: 1.03,1.69]). Several fetal biometric measures were significantly associated with SD when dichotomized based on clinically selected cut-off points. A final prediction model was internally valid with an area under the curve of 0.90 (95% confidence interval: 0.81, 0.99). At a model probability of 1%, sensitivity (71.4%), specificity (77.5%), positive (3.5%), and negative predictive values (99.6%) did not indicate the ability of the model to predict SD in a clinically meaningful way.

CONCLUSION

Other than epidural anesthesia use, neither sociodemographic nor maternal anthropometrics were significantly associated with SD in this low-risk population. Both individually and in combination, fetal biometrics had limited ability to predict SD and lack clinical usefulness.

KEY POINTS

· SD unpredictable in low-risk women.. · Fetal biometry does not reliably predict SD.. · Epidural use associated with increased SD risk.. · SD prediction models clinically inefficient..

摘要

目的

本研究旨在评估低危产科人群中胎儿生物测量指标与肩难产(shoulder dystocia,SD)的相关性。

研究设计

参与者作为美国一项基于前瞻性队列的低危单胎妊娠胎儿生长研究的一部分被纳入研究( = 2802)。符合条件的孕妇为阴道分娩的活产单胎婴儿体重≥2500 克。研究人员提取社会人口统计学、人体测量学和妊娠结局数据。SD 的诊断基于分娩医生的临床印象记录。采用简单逻辑回归模型检验胎儿生物测量指标与 SD 之间的相关性。通过 Youden 的 J 和临床判断选择胎儿生物测量截断值,以优化预测能力。使用向后选择构建 SD 预测的最终模型。我们的数据集随机分为训练(60%)和测试(40%)数据集,用于模型构建和内部验证。

结果

共有 1691 名妇女(98.7%)阴道分娩顺利,23 名(1.3%)发生 SD。两组间社会人口统计学或产妇人体测量指标无差异。与未发生 SD 的孕妇相比,发生 SD 的孕妇使用硬膜外麻醉的比例显著更高(100%比 82.4%; = 0.03)。SD 病例的羊水最大垂直袋也显著更大(5.8 ± 1.7 比 5.1 ± 1.5 cm;比值比 = 1.32 [95%置信区间:1.03,1.69])。当根据临床选择的截断值将胎儿生物测量指标分为两类时,几项指标与 SD 显著相关。最终预测模型具有内部有效性,曲线下面积为 0.90(95%置信区间:0.81,0.99)。在模型概率为 1%时,该模型的灵敏度(71.4%)、特异性(77.5%)、阳性预测值(3.5%)和阴性预测值(99.6%)均表明该模型无法以有临床意义的方式预测 SD。

结论

除了硬膜外麻醉的使用,在这个低危人群中,社会人口统计学或产妇人体测量指标与 SD 均无显著相关性。胎儿生物测量指标单独或联合使用时,预测 SD 的能力有限,缺乏临床实用性。

重点

· SD 在低危女性中无法预测。

· 胎儿生物测量不能可靠预测 SD。

· 硬膜外使用与 SD 风险增加相关。

· SD 预测模型临床效率低。

相似文献

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Population-Based Risk Factors for Shoulder Dystocia.基于人群的肩难产风险因素
J Obstet Gynecol Neonatal Nurs. 2018 Jan;47(1):32-42. doi: 10.1016/j.jogn.2017.11.011. Epub 2017 Dec 6.
4
The FL/AC ratio for prediction of shoulder dystocia in women with gestational diabetes.
J Matern Fetal Neonatal Med. 2017 Oct;30(19):2378-2381. doi: 10.1080/14767058.2016.1249842. Epub 2016 Nov 8.
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Parental obesity and risk of autism spectrum disorder.父母肥胖与自闭症谱系障碍风险
Pediatrics. 2014 May;133(5):e1128-38. doi: 10.1542/peds.2013-3664. Epub 2014 Apr 7.

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