MacDonald J B, MacDonald E T
Br Med J. 1977 Aug 20;2(6085):483-5. doi: 10.1136/bmj.2.6085.483.
A survey of 390 patients aged over 65 with fractured femurs showed that nearly all the fractures that had been caused by nocturnal falls had occurred among the many patients who were still taking barbiturate hypnotics. Barbiturates were also strongly associated with a history of frequent falls. Barbiturates are still prescribed surprisingly often for the elderly. An analysis of 1622 elderly patients referred to a geriatric clinic in Nottingham showed that 41% were taking barbiturates in 1973. By 1976 this fugure had actually increased to 51%, despite the substantial campaign against barbiturate prescribing. This campaign thus appears to have made little or no impact on prescriptions for the elderly in at least one large town. The dangers of barbiturates may well need constant reemphasis.
一项针对390名65岁以上股骨骨折患者的调查显示,几乎所有夜间跌倒导致的骨折都发生在众多仍在服用巴比妥类催眠药的患者中。巴比妥类药物还与频繁跌倒史密切相关。令人惊讶的是,巴比妥类药物至今仍经常被开给老年人。对诺丁汉一家老年诊所收治的1622名老年患者进行的分析表明,1973年有41%的患者在服用巴比妥类药物。到1976年,尽管开展了大规模反对开具巴比妥类药物处方的运动,但这一数字实际上增至51%。因此,至少在一个大城镇,这场运动似乎对老年人的处方用药几乎没有产生影响。巴比妥类药物的危险性很可能需要不断地再次强调。