老年人中的巴比妥类药物与血清钙
Barbiturates and serum calcium in the elderly.
作者信息
Young R E, Ramsay L E, Murray T S
出版信息
Postgrad Med J. 1977 Apr;53(618):212-5. doi: 10.1136/pgmj.53.618.212.
Abstract
In a retrospective study, based on a biochemical survey of people aged 65 and over in a general practice, subjects taking a barbiturate preparation for indications other than epilepsy had a significantly lower serum calcium concentration than did those taking nitrazepam or diazepam. Ordinary doses of barbiturate may adversely affect vitamin D metabolism in the elderly.
摘要
在一项回顾性研究中，基于对一家普通诊所65岁及以上人群的生化调查，因非癫痫适应症而服用巴比妥酸盐制剂的受试者血清钙浓度显著低于服用硝西泮或地西泮的受试者。普通剂量的巴比妥酸盐可能会对老年人的维生素D代谢产生不利影响。
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本文引用的文献
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Disturbance of calcium metabolism by anticonvulsant drugs.抗惊厥药物对钙代谢的干扰。
Br Med J. 1970 Oct 10;4(5727):73-6. doi: 10.1136/bmj.4.5727.73.
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Osteomalacia with long-term anticonvulsant therapy in epilepsy.癫痫患者长期抗惊厥治疗导致的骨软化症。
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Changes in plasma -glutamyl transpeptidase activity associated with alterations in drug metabolism in man.人血浆γ-谷氨酰转肽酶活性变化与药物代谢改变的关系。
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Osteomalacia after prolonged glutethimide administration.长期服用格鲁米特后出现骨软化症。
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Barbiturate and anticonvulsant treatment in relation to osteomalacia with haemodialysis and renal transplantation.
Br Med J. 1976 Jan 24;1(6003):190-3. doi: 10.1136/bmj.1.6003.190.
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Actions of vitamins D2 and D3 and 25-OHD3 in anticonvulsant osteomalacia.维生素D2、D3和25-羟基维生素D3在抗惊厥药所致骨软化症中的作用
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