两种新型生殖器人乳头瘤病毒（HPV）类型，HPV68和HPV70，与具有潜在致癌性的HPV39相关。
Two novel genital human papillomavirus (HPV) types, HPV68 and HPV70, related to the potentially oncogenic HPV39.
作者信息
Longuet M, Beaudenon S, Orth G
机构信息
Unite Mixte Institut Pasteur (Unite des Papillomavirus)-Institut National de la Sante et de la Recherche Medicale, Paris, France.
出版信息
J Clin Microbiol. 1996 Mar;34(3):738-44. doi: 10.1128/jcm.34.3.738-744.1996.
Abstract
The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low-grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and partially sequenced. Both types are related to HPV39, a potentially oncogenic virus. HPV68 and HPV70 were also detected in genital intraepithelial neoplasia from three patients and one patient, respectively. Comparison with sequence data in the literature indicates that the subgenomic ME180-HPV DNA fragment, cloned from a carcinoma cell line, corresponds to an HPV68 subtype and that several HPV DNA fragments amplified by PCR from genital neoplasia represent worldwide distributed variants of HPV68 and HPV70.
摘要
两种新型人乳头瘤病毒（HPV）——HPV68和HPV70，分别从低度宫颈上皮内瘤变组织和外阴乳头瘤中克隆出来，并进行了部分测序。这两种类型均与具有潜在致癌性的病毒HPV39相关。分别在三名患者和一名患者的生殖器上皮内瘤变中也检测到了HPV68和HPV70。与文献中的序列数据比较表明，从癌细胞系克隆的亚基因组ME180-HPV DNA片段对应于HPV68的一个亚型，并且通过PCR从生殖器瘤变中扩增出的几个HPV DNA片段代表了HPV68和HPV70在全球范围内分布的变体。
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