萨尔瓦地腺苷，一种来自巴哈马被囊动物Didemnum sp.的5'-脱氧-5'-(甲硫基)核苷。

Jamison Matthew T, Boddy Christopher N, Molinski Tadeusz F

Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and §Department of Pharmaceutical Sciences, University of California, San Diego , La Jolla, California 92093-0358, United States.

J Org Chem. 2014 Nov 7;79(21):9992-7. doi: 10.1021/jo501486p. Epub 2014 Oct 20.

Salvadenosine, (1) a rare 5'-deoxy-5'-(methylthio) nucleoside, was isolated from the deep-water Bahaman tunicate Didemnum sp. The structure was solved by integrated analysis of MS and 1D and 2D NMR data. We revise the structure of the known natural product, hamiguanosinol, which is a constitutional isomer of 1, to 5 by interpretation of the spectroscopic data and comparison with synthesized nucleosides.

萨尔瓦地腺苷（1）是一种罕见的5'-脱氧-5'-（甲硫基）核苷，从巴哈马深海被囊动物Didemnum sp.中分离得到。通过对质谱以及一维和二维核磁共振数据的综合分析确定了其结构。通过对光谱数据的解读并与合成核苷进行比较，我们将已知天然产物哈米胍醇（它是1的构造异构体）的结构修正为5。