Aiello Anna, Fattorusso Ernesto, Giordano Antonella, Menna Marialuisa, Navarrete Carmen, Muñoz Eduardo
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Bioorg Med Chem. 2007 Apr 15;15(8):2920-6. doi: 10.1016/j.bmc.2007.02.015. Epub 2007 Feb 13.
The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A-F (1-6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.
对地中海海鞘Phlegraea clavelina的化学研究已导致分离出六种新的2-氨基-3-烷醇衍生物，即clavaminols A-F（1-6）。通过光谱数据分析和化学转化确定了它们的立体结构。测试了clavaminols A、B、C和F的细胞毒性和促凋亡特性，结果表明clavaminol A是该系列中更具细胞毒性的化合物，可通过激活凋亡机制诱导细胞死亡。
